WHERE CAN I FIND A NEW STOOL?

[MPN-MATE Admin]

Evening all,

This article holds a great deal of promise for many of us. Diet, and the changing of the gut biome is often required to improve one's general health, however, it is not always that simple. Perhaps until now, as a few scientists have found a better way to achieve this task...

Have a listen to the following:



Best wishes all...

Steve

[mocha38]

Interesting! Thank you for sharing. But I think I'll try taking probiotic first. Hopefully it helps too , and does not interfere with Pegasys and Hydrea

[MPN-MATE Admin]

Hey Mocha...

Welcome to the FORUM, great to have you pop in...

Yes, it's one of those subjects that does sound really icky-kak... But it is really quite fascinating too. Many people are simply unable to change their dietary regime because of a poor gut biome. This method of changing it is said to be far superior to a 'Probiotic' as one must simply keep taking them, whereas, once the gut colonises the new bacteria, the 'Gut Biome' is permanently altered etc...

Anyways, it will be interesting to watch it all develop too in the meantime...

Hope to talk more again soon...

Best wishes

Steve

[MPN-MATE Admin]

Had to add this one here too...

Remodeling unhealthful gut microbiomes with the help of synthetic peptides

Reviewed by James Ives, M.Psych. (Editor)Aug 27 2019

You are what you eat -; right down to the microbiome living in your gut. Diet can affect which microbes are in the intestinal tract, and research has shown that harmful gut microbiome changes can lead to illnesses such as heart disease, obesity and cancer. Today, scientists will report the development of molecules that can change, or remodel, unhealthful gut microbiomes in mice into more healthful ones. The research could also someday be applied to other conditions related to diet.

The researchers will present their results at the American Chemical Society (ACS) Fall 2019 National Meeting & Exposition. ACS, the world's largest scientific society, is holding the meeting here through Thursday. It features more than 9,500 presentations on a wide range of science topics.

The gut microbiome contains hundreds of different species of bacteria and is where the largest concentration of bacteria living in us resides. If we all ate a healthy diet, exercised and didn't age, we wouldn't have problems with our gut microbiome and many diseases. But, that's not how all people live. Current methods aimed at improving the makeup of gut microbiomes have involved prebiotics, probiotics or drug therapies. Our goal was to take a totally new approach -; to remodel the microbiome."

M. Reza Ghadiri, Ph.D., leader of the study
The key to the research is a class of molecules called self-assembling cyclic D, L-α-peptides. They were created in Ghadiri's laboratory originally to kill pathogenic bacteria. Peptides are short chains of amino acids linked together; they are the building blocks of proteins. Ghadiri's peptides are not found in nature and have a highly specific mode of activity and selectivity against different bacterial species.

"Our hypothesis was that instead of killing bacteria, if we could selectively modulate the growth of certain bacteria species in the gut microbiome using our peptides, more beneficial bacteria would grow to fill the niche, and the gut would be 'remodeled' into a healthful gut," Ghadiri explains. "Our theory was that process would prevent the onset or progression of certain chronic diseases."

To test this hypothesis, Ghadiri chose cardiovascular disease and used a strain of mice known as LDL receptor knockout mice.

"These mice have been bred to thrive on low-fat diets, but when they are fed a diet high in saturated fat -; a so-called Western diet -; they develop high plasma cholesterol, especially the LDL or 'bad' type," Ghadiri explains. "Within 10 to 12 weeks, they develop plaques in their arteries such as you would find in atherosclerosis patients."

LDL receptor knockout mice are the "gold standard" to test the effectiveness of statins, which are widely used to reduce cholesterol levels.

Head-to-head comparison of three breast cancer drugs reveals important differences
Blood sugar levels linked to DNA damage and cancer in diabetics

Researchers target cancer's protective barrier

To find the best peptides to test on the mouse model, the team developed a mass screening assay. The scientists grew a representative mouse microbiome in the lab and then tested various peptides with it. Ghadiri then selected two peptides that appeared to be the most effective for remodeling the mouse gut microbiome into a state resembling the gut microbiome of the mice on a low-fat diet.

The subsequent study included three groups of mice. One group was fed a low-fat diet, another group was fed a Western diet, and a third group was fed a Western diet plus oral doses of one or the other of the two peptides. From fecal samples, the researchers sequenced the gut microbiome from all three groups before and after dosing. They also measured the levels of molecules that affect the immune system, inflammation and metabolism, and examined the animals' arteries for plaques.

"Mice fed the Western diet with our peptides had a 50% reduction in total plasma cholesterol, and there was no significant plaque in the arteries, compared to the mice fed a Western diet and no peptides," Ghadiri says. "We also saw suppressed levels of molecules that increase inflammation and rebalanced levels of disease-relevant metabolites. These mice resembled those on a low-fat diet."

The mechanisms by which this takes place most likely involve genes that affect bile acids, which in turn affect the metabolism of cholesterol, as well as other genes that affect inflammatory processes such as atherosclerosis, Ghadiri says.

"This is the first time anyone has shown that there are molecules to purposefully remodel the gut microbiome and turn an unhealthful gut into a more healthful one," he says. "This opens up clear therapeutic possibilities. We can sequence the guts of individuals and eventually develop therapies."

"The gut microbiome contains hundreds of different species of bacteria and is where the largest concentration of bacteria living
in us resides. If we all ate a healthy diet, exercised and didn't age, we wouldn't have problems with our gut microbiome and
many diseases. But, that's not how all people live. Current methods aimed at improving the makeup of gut microbiomes
have involved prebiotics, probiotics or drug therapies. Our goal was to take a totally new approach; to remodel the microbiome."

M. Reza Ghadiri, Ph.D., leader of the study

https://www.news-medical.net/news/20190 ... tides.aspx


All of this sounds extremely promising to me...

Best wishes
Steve


REFERENCE

[SilverET]

Hi Steve,

Interesting article. Some of the research work I used to do involved trying to improve animal production by altering the the microbiome of the animal. This can be done, however once an animal (include humans here too) has established it's gut environment early on in life it is extremely difficult to make any changes to the microbiome stick. The environment tends to lead to the range of bacteria reverting back to what was there originally as it has already been set up to suit them better. Improvements can be made but it is usually an ongoing process so any pro- or pre-biotics or any peptides introduced need to be given long term or the microbiome will drift back to it's previous state over time. The best way to make sure people and animals have a good microbiome and gut is to set it up at birth and we now know that this means that what Mum eats during pregnancy is crucial to this. Not only that but what Dad eats around conception plays a role too.
For example hens that were fed a balanced fat ration in their diet during egg laying produced chicks with enhanced resistance to disease and also had better feed conversion. ie had more lean muscle growth from the same feed than their counterparts whose Mum's were fed different fat ratios.
Take home message from the chickens was don't go too far down the plant only fats road or the animal fat only road. It is important to have both fats from animals and plants in a balanced way for a healthy immune system and good gut. So the old 'butter is bad' thing is total bollocks. The human research world is only just starting to realise this but still have not changed recommendations for a healthy diet.

Hope you are travelling OK and watching a bit of the Spanish cycling.

Regards,
SilverET

[socrates_8]

Hey Natasha...

Firstly, please forgive my tardy reply this evening... Has been a rather full day... Cycled 113kms today, and then have had one or two chores to complete...

Lovely of you to drop by too... Been a while...

I hear you on the Dietary side of things... However, I have not eaten any meat for many years now...

I am a Pescetarian these days... Prefer wild-caught of course, when I can get it. Otherwise, I just try to be as sustainable as possible...

I shudder with great fear every-time I hear yet another story about the demise of the Earth's lungs – The Amazon Rain Forest... All mainly done to harvest ever more beef... Just as I do when watching the ever-accelerating demise of our Great Barrier Reef...

Scientists, recently showed how snow falling in Antarctica was full of plastic particle matter, and a great deal of it too... We might all need to start wearing a mask – Full–time!

Hence, in my mind, there are many other very real reasons why we all need to look more closely at what we are doing to this beautiful Pale-Blue-Dot...


However, when discussing the 'Gut Biome' as we once were...

The planting of a stool, sounds like it may have some merit... Once one moves past the 'Cack' factor...

Yes, the Vuelta is deemed to be the toughest cycling race of all ...

However, these longer rides are all tough for me really. I just grind it out, and I am certainly no natural... But I do enjoy it too... However, I am no racer myself, just learning to be an endurance performer... All sorts of tricks must be employed to be successful, and training harder, makes me better at understanding so much of what I must endeavour to do...

A few nights back was a fascinating documentary of Lance Armstrong – "The Armstrong Lie" fascinating to watch... It was on channel Seven (7) I believe. Definitely worth watching. For all Armstrong's faults and aberrant behaviour, he did also create an incredible Cancer Foundation called – "Live Strong" and they have done some incredible work already...

Anyways... I shall move on to answering your other Posts now...

Steve