MATEs FORUM

Hi, I wonder if MPN'ers have already had experience with Resveratrol. A comparative study in 2013 shows that Resveratrol has a more powerful effect than Ruxolitinib in combating the JAK2617f clone. However, after this research I see nothing about patiënt studies on the internet.
See:
https://ashpublications.org/blood/artic ... Cell-Lines
and
https://pubmed.ncbi.nlm.nih.gov/26375873/

Regards Paul

Hey Paul... 8-D

Great to hear from you too...

I did have a quick glance at those two (2) articles you provided a HyperLink for...

Being completely honest, can't say that I have ever heard of "Resveratrol" (R) previously... However, seems to be big in the anti-aging arena...

Your citations did make for some interesting reading, however, I have not looked more closely at them as yet, but I shall shortly... I've just returned from a Ride. So nice to have spent some time in the sun again...

I did find one other Reference for R, and I have placed that below for you.

Hope you might join us for a quick 'Virtual Cafe Catchup' this Sunday at 6pm...

But no worries if you can't make it...

Stay safe, happy & well Paul...

Steve

PS. Paul not sure if you noticed, "When making a Post, be sure to Tick the "Subscribe" to this Post button on the Left Hand side above & alongside "New Topic". Then you'll be notified whenever anyone replies to your Posts etc... Regards. S

REFERENCE:

Shaito, Abdullah et al. 2020. “Potential Adverse Effects of Resveratrol: A Literature Review.” International journal of molecular sciences vol. 21,6 2084. 18 Mar. 2020, doi:10.3390/ijms21062084
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139620/

Thanks Steve!
It's anything but sunny here in the Netherlands
I saw another interesting article about a comparison study of resveratrol with hydrea. I don't know if I understand correctly but it seems here that Resveratrol also has a stronger effect than Hydrea in suppressing ribonucleotide reductase. I thought this is the mechanism of action through which Hydrea leads to cell control..

https://www.sciencedirect.com/science/a ... 20%5B11%5D.

Regards Paul

Hi again & thanks Paul...

Yes, I'm sure it's a tad cooler in the Netherlands too...

It is an interesting Paper, however, still worth noting that there appears to be a great deal more research needed beforehand...

Still, very interesting none the less. Anything must be better than Hydroxyurea (HU). That is a dreadful drug in my view. While it does help to reduce high Platelets, it seems to have a few too many adverse side-effects as the trade-off, in my view...

I shall keep my ear to the ground to developments w/ RE into the future too...

Thanks Paul...

Stay safe & happy my friend.

Steve

PS. Belated footnote too Paul: Red wine is apparently helpful where RE is concerned...

See also:
Resveratrol targets PD-L1 glycosylation and dimerization to enhance
antitumor T-cell immunity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977679/
Regards, Paul